Ladies who are afflicted by cancer of the breast in a youthful age have certain bits of their DNA missing: Study

By: IANS Wellington Printed:May 29, 2017 7:01 pm

breast cancer, causes of breast cancer, how to prevent breast cancer, medical developments in breast cancer, indian express, indian express news

The research was conducted in collaborative with scientists in the College of Melbourne around australia.
(Source: File Photo)

Inside a thought that may help find methods to prevent cancer of the breast, researches have proven that ladies who get the condition in a youthful age have certain bits of their DNA missing. The invention could contain the answer to helping youthful women beat the condition, based on the researchers who studied the DNA of countless Australian women aged under 40 who’d developed cancer of the breast.

“We were looking for genetic causes why they developed the condition at this kind of young age,Inches stated Logan Master from College of Otago, Christchurch, Nz. The ladies “missed” certain items of their DNA, demonstrated the findings printed within the journal Cancer Of The Breast Research.

“We think these bits of DNA which are missing might have overlapped genes or involved genes which have led to the first start of cancer of the breast,” Master stated, adding he hopes the finding could eventually identify women vulnerable to developing cancer in a youthful age, and improve treatment and survival rates.

ALSO READ  More than 1 glass of vino each day may trigger cancer of the breast risk

“If we are able to find out the genes that underlie risk, or the types of stuff that cause disease during these youthful women, only then do we could possibly identify individuals women prior to the disease has happened, and when are going to that people can minimise the chance of or avoid the disease from occurring to begin with,Inches Master stated.

The research was conducted in collaborative with scientists in the College of Melbourne around australia.

“Genetic testing typically implies that 10 percent of youthful ladies who develop cancer of the breast have inherited a mutation in known cancer of the breast susceptibility genes – probably the most broadly publicised being BRCA1 and BRCA2,” Master stated. “This leaves a lot of the youthful women without any explanation. We are attempting to change this through our work together with large worldwide studies using cutting-edge DNA analysis tools,” he stated.

To verify the findings of his study, the DNA of thousands of women from around the globe ought to be checked, Master stated.

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Vitamin D while pregnant prevents bronchial asthma in kids : Study

By: PTI London Printed:May 29, 2017 7:44 pm

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Based on researchers, taking Vitamin D supplements while pregnant increases the babies’ defense mechanisms and could prevent bronchial asthma and respiratory system infections. (Source: Thinkstock Images)

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Taking vitamin D supplements while pregnant strengthens the babies’ defense mechanisms, which might lower their chance of developing bronchial asthma and respiratory system infections, new research claims.

“The most of all bronchial asthma cases are diagnosed when they are young implying the origin from the disease stems in foetal and early existence,” stated Catherine Hawrylowicz, professor at King’s College London within the United kingdom.

Researchers checked out the result that going for a supplement of four,400 IU (Worldwide Units) vitamin D3 each day throughout the second and third trimesters of being pregnant in comparison to the suggested daily intake (RDI) of 400 IU/day, had around the defense mechanisms from the newborn.

Participants were randomised at 10-18 days of being pregnant to low or high doses of vitamin D supplements.

They then required umbilical cord bloodstream from about 51 women that are pregnant to check the responsiveness from the newborn’s innate defense mechanisms, which make up the body’s first type of defence to infection, and T lymphocyte (white-colored bloodstream cells) responses, which offer longer-lasting protection.

They discovered that bloodstream samples from babies born to moms supplemented with greater vitamin D3 taken care of immediately mimics of virus stimulation by greater innate cytokine responses and greater IL-17A production as a result of T lymphocyte stimulation.

Both kinds of response are predicted to enhance neonatal defence to infection, researchers stated.Because of the evidence for strong immune responses at the begining of existence being connected with decreased growth and development of bronchial asthma, researchers believe the result will probably result in improved respiratory system health in early childhood.

“Vitamin D is really a promising section of research for bronchial asthma. Even though this study implies that vitamin D supplementation during pregnancy may improve immune responses, a lot more research is required to prove whether this may actually result in reduced bronchial asthma rates later in existence,” Hawrylowicz stated.

The research was printed within the Journal of Allergy and Clinical Immunology.

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To Become Sick Without Obamacare

Those who have any type of medical problem are in the centre from the debate over repealing and replacing the Affordable Care Act. In regards to a quarter of adults under 65 have these so-known as preexisting conditions, and they’re most susceptible to any change in the present law, which prohibits charging sick people more for insurance. The substitute bill that passed home of Representatives, the American Healthcare Act, allows states to complete exactly that for those who have a niche of 63 days within their insurance policy. It might also allow insurers to prevent covering certain services, even for those who have continuous coverage. An believed 23 percent of people that were built with a gap within their insurance policy in 2015 also were built with a preexisting condition.

Underneath the House bill, insurers couldn’t deny customers policies altogether—something that became of 18 percent of people that requested coverage prior to the ACA. Here’s the rather infamous example from 2009 of “Baby Alex”—a 4-month-old who had been, at 17 pounds, considered uninsurably fat, based on ABC News:

Baby Alex, who’s 25 inches lengthy and weighs 17 pounds, grouped into the 99th percentile for weight and height for his age, based on Cdc and Prevention guidelines. Rocky Mountain Health Plans insurance underwriters used individuals guidelines to deny coverage for Alex since he was over the 95th percentile, saying he’d a “preexisting condition” of weight problems.

(For the reason that situation, media scorn saved your day, and Alex got his coverage within the finish.)

But underneath the new bill, there isn’t any limit on what insurers could charge people according to health problems they’ve. In claims that requested waivers to charge more, insurers “would charge high prices, and individuals wouldn’t have the ability to afford it,” states Gary Claxton, the director from the Healthcare Marketplace Project in the Kaiser Family Foundation. “It could be pretty very similar as declining them.”

This could happen because of a cruel actuarial reality: Insurers can’t manage to cover only those who have severe health needs. There need to be many people having to pay in who aren’t likely to use their insurance coverage greatly. If your condition waived the fundamental health benefits—the listing of 10 services, like mental-health insurance and maternity care, that Obamacare needed insurers to cover—insurers may likely sell bare-bones policies, together with comprehensive policies that covered a variety of health conditions. However the only individuals who would join the excellent plans could be individuals who needed them. So insurers, consequently, would either raise their rates or stop providing the plans entirely.

One of the customers that insurers would surcharge before Obamacare were ladies who had Caesarian sections—that is, when they didn’t deny them outright, as
The Brand New You are able to Occasions demonstrated in 2008:

Blue Mix Blue Shield of Florida, that has about 300,000 people with individual coverage, accustomed to exclude repeat Caesareans, but lately started to pay for them—for a 25 % rise in premiums for 5 years.

Claxton (and also the Congressional Budget Office) also recommended that, if healthy people finish up obtaining a discount on their own insurance, some might take part in the system. They might avoid telling insurers that they are continuously covered—thus qualifying for that cheaper, healthy rate. When they switched insurers every open enrollment period, there’d not be any method to keep an eye on whether or not they were continuously covered or otherwise.

“This means healthy people keep bouncing around and becoming reduced rates, and also the rates for those who don’t do that carry on up,” he states. “The those who are sick would always get creamed.”

In 2001, his organization, the Kaiser Family Foundation, produced fake applicants and sent these to insurance providers to determine the way they could be treated. One hypothetical 56-year-old lady named Emily received a number of tough responses from insurance providers after disclosing she was on Prozac, based on the Bay Area Chronicle:

Twenty-3 % from the insurers surveyed rejected her, another 23 percent quoted her a greater rate, 12 % offered her benefits that excluded strategy to mental disorders and 27 percent offered her both greater rates and limited benefits.

In addition to this, there’s nothing within this bill saying states must generate a high-risk pool to pay for every sick individual who can’t afford insurance otherwise, Claxton states. There may, essentially, be nowhere for those who have preexisting conditions to visit.

Another factor that may return, he states, is really a process known as rescission—where insurers would retroactively cancel the policies of consumers who unsuccessful to say a physical disease on their own initial applications.

Here’s a good example of how rescission accustomed to work, using a 2009 Washington Publish story:

“They stated Irrrve never pointed out I’d a back problem,” stated Marrari, 52, whose coverage with Blue Mix was abruptly canceled in the year 2006 following a thyroid disorder, fluid within the heart and lupus were diagnosed. That left the la lady with $25,000 in hospital bills and also the stigma from the company’s declare that she’d committed fraud by not listing on the health questionnaire “preexisting conditions” Marrari stated she didn’t know she’d.

And here’s another example, via CNN, of the lady whose coverage was rescinded because she listed her weight incorrectly coupled with since began going for a new medication:

“I did not get sound advice. A healthcare facility wanted a $30,000 deposit. I had been on my own. I did not obtain that type of money,” Beaton stated through tears. “Can you would imagine, getting just to walk around with cancer growing within your body? Without any insurance. It is the most terrifying factor on the planet not to have anybody to go to or anywhere to visit.Inches

Applications for insurance, Claxton states, might start looking similar to this, with applicants likely to list each time they’ve seen a physician previously 2 yrs.

The Senate is debating its very own form of an Obamacare repeal bill now, and it is important to note that it is not obvious where they’ll find both of these waivers. Axios reports, citing several Republicans aides, the Senate form of the balance won’t allow states to charge sick people more, and can permit them to waive the fundamental health advantages. For the reason that situation, some, although not all, of those pre-Obamacare problems would return. Vox, meanwhile, is reporting the Senate will purposefully have a unsuccessful election to ensure that Congress can be achieved with health-care reform entirely. Meanwhile, Republicans within the Senate say they’re “very cognizant” of preexisting conditions, as Republican Senator Bill Cassidy place it to Politico.

On the other hand, that’s what House leaders stated, too.

“They stored saying the balance covers individuals with preexisting conditions,” Claxton stated, talking about the home bill’s sponsors. “Facing limitless premiums just is that not.Inches

Once-a-month diabetes treatment may replace daily insulin jabs

By: PTI Washington Printed:June 6, 2017 11:52 pm

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Many current treating diabetes type 2 make use of a signalling molecule known as glucagon-like peptide-1. (Source: File Photo)

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Scientists, including certainly one of Indian origin, allow us a technology that could provide days of glucose control for diabetes having a single injection, which will be a dramatic improvement over current therapies. In primates, the therapy continues to be proven to continue for days, instead of days, researchers at Duke College in america stated.

ALSO READ  Watching TV for several hrs daily may up diabetes risk in kids

By developing a controlled-release mechanism for any drug and optimising its circulation time in your body, the brand new biopolymer injection can replace daily or weekly the hormone insulin having a once-a-month or two times-a-month treating diabetes type 2, they stated.

Many current treating diabetes type 2 make use of a signalling molecule known as glucagon-like peptide-1 (GLP1) to result in the pancreas to produce insulin to manage bloodstream sugar. However, this peptide includes a short half-existence and it is removed in the body rapidly. Researchers, including Ashutosh Chilkoti, from Duke College, have produced a technology that fuses GLP1 to some heat-sensitive elastin-like polypeptide (ELP) inside a solution that may be injected in to the skin via a standard needle. Once injected, the answer responds to body heat to create a biodegradable gel-like “depot” that gradually releases the drug because it dissolves.

In animal experiments, the resulting therapy provided glucose control as much as three occasions more than treatments presently available on the market. Researchers systematically labored to alter the style of the delivery biopolymer in the molecular level and located a sweet place that maximised the time period of the drug’s delivery from one injection. “By doing this, we were able to triple the time period of this short-acting drug for diabetes type 2, outperforming other competing designs,” stated Chilkoti, senior author of study published within the journal Nature Biomedical Engineering. Researchers optimised their means to fix regulate blood sugar levels in rodents for ten days following a single injection, up in the previous standard of two-three days.

In further tests, they discovered that the optimised formulation improved glucose control in rhesus apes in excess of fourteen days following a single injection, whilst releasing the drug in a constant rate throughout the trial. “What is exciting relating to this work was our capability to show the drug could last over two days in non-human primates,” stated Kelli Luginbuhl, a PhD student within the Chilkoti lab and co-author from the study.

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Consuming teas could make you lose touch with reality

By: PTI London Printed:June 7, 2017 12:15 am

A 25-year-old man in Italia is promoting psychosis – an ailment in which the patient loses touch with reality – after regularly consuming a natural tea, based on doctors who warn against consuming certain herbs without prescription. The patient’s condition improved after he received strategy to psychosis, doctors authored within the report printed within the Journal of Medical Situation Reports.

ALSO READ  Tea lover? Here are a few advantages of consuming three different teas

The person was introduced to AUSL Modena hospital in Italia by his buddies, who told the doctors he have been acting oddly for many days. The doctors examined the individual and observed he was getting speech problems and it was experiencing instances of paranoid thinking and delusions. They diagnosed him with schizophreniform disorder – a kind of mental disorder which involves psychosis. They gave him antipsychotic medications, and 2 days after his admission, his condition improved, ‘Live Science’ reported.

Throughout his follow-up treatment, it emerged that three several weeks just before his psychotic episode, the person had began feeling weak and exhausted coupled with severe stomach discomfort. He eventually saw a physician, who determined the man had numerous stomach erosions as well as an infection of Helicobacter pylori – a kind of bacteria recognized to cause stomach ulcers. However, rather of using the medication the physician prescribed to deal with individuals signs and symptoms, the person made the decision to self-medicate with tea created using St John’s wort – a plant recognized to have therapeutic qualities.

He’d been consuming four glasses of the tea each day until he was accepted towards the hospital for his psychotic episode. It’s impossible to find out with certainty if the tea caused the man’s psychotic episode, the doctors authored. However, the teas “could have performed a determinant role within the onset” from the man’s signs and symptoms, they authored. “St John’s wort (Hypericum perforatum) is known for hundreds of years because of its therapeutic qualities, and it is effectiveness being an antidepressant is proven with a growing body of evidence,” doctors stated.

However the herb’s “availability without prescription, being an over-the-counter medication, raises some concern regarding its clinical management and without supervision administration to the people with” mental health problems, they stated.

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Deciding If Double Knee Substitute Fits your needs

News Picture: Deciding If Double Knee Replacement Is Right for You

Latest Joint disease News

FRIDAY, June 2, 2017 (HealthDay News) — Patients deciding whether to possess a double knee substitute must think about the benefits and drawbacks, an memory foam surgeon states.

“Lots of people wish to have a dual knee substitute simply because they feel they are able to have it over and done with faster since there’s one surgery, one stay in hospital and something span of rehabilitation,” stated Dr. Geoffrey Westrich.

Known as a “bilateral procedure,” double knee substitute enables individuals with seriously arthritic knees to return to their normal lives faster, “but for the right patient, it is a good option,” stated Westrich. He’s research director of adult renovation and joint substitute in the Hospital for Special Surgery in New You are able to City.

“However, double knee substitute isn’t for everybody, and individuals ought to be well-informed before making the decision,Inch he added.

Double knee substitute includes a greater rate of complications, including heart disease and thrombus. Patients shed more pounds bloodstream, so are more inclined to require a bloodstream transfusion, and rehabilitation is a lot more demanding, Westrich stated.

Patients should be in excellent health, besides the joint disease, and also have no underlying health issues, he described.

Because of the greater chance of complications, double knee replacements aren’t performed in patients over the age of 75, Westrich stated.

“Not very lengthy ago, people believed that should you have had one knee replaced, the discomfort and rehab could be so taxing you wouldn’t like to return for surgery alternatively knee,” he stated inside a hospital news release.

“But nowadays, with advances in surgical techniques, anesthesia and discomfort management, the recovery for any single knee substitute in a high-volume joint substitute center is a lot simpler and quicker than it had been previously. Within our experience, just about any patient returns for that second knee substitute,” Westrich stated.

Patients typically wait a minimum of three several weeks between surgeries, he stated.

Another essential consideration is the fact that some patients go back home following a single knee substitute, individuals who’ve a dual knee substitute more often than not spend some time inside a rehabilitation facility after surgery, Westrich stated.

— Robert Preidt

MedicalNews
Copyright © 2017 HealthDay. All legal rights reserved.

SOURCE: Hospital for Special Surgery, news release

‘Forceps, vacuum deliveries more traumatic than C-section’

By: IANS Toronto Updated: June 6, 2017 10:42 pm

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Moms face ten occasions more serious birth trauma because of tear and bloodstream loss! (Source: ThinkStock Images)

When compared with Caesarean section deliveries, midpelvic deliveries with forceps and vacuum could cause greater trauma to moms and babies, new research has stated. Midpelvic operative vaginal deliveries using forceps or vacuum application are transported out once the baby’s mind is halfway with the mother’s pelvis.

Conditions like foetal distress during work causes it to be imperative for forceps and vacuum use because they have the possibility in order to save lives, because these methods save your time in contrast to a C-section delivery. In 2014, the American College of Obstetricians and Gynaecologists encouraged elevated utilization of forceps and vacuum delivery to lessen rates of deliveries by Caesarean section. However, babies delivered through midpelvic operative deliveries had 80 % greater rates of severe complications. Moms faced ten time more serious birth trauma because of tear and bloodstream loss.

“Our study shows that unless of course we are able to improve our capability to select candidates for midpelvic forceps and vacuum deliveries, or improve learning such deliveries, encouraging greater rates of mid pelvic operative deliveries could increase rates of neonatal complications,” stated lead author Giulia Muraca, doctorate investigator in the College of Bc (UBC).

These complications usually involve birth traumas, in addition to maternal complications for example severe postpartum haemorrhage, and obstetric trauma for example tearing, Muraca stated. Researchers believe that women ought to be informed from the harms in addition to their consent ought to be taken when such surgical and medical interventions should be transported out.

For that study, appearing within the Canadian Medical Association Journal, they checked out data on 187,234 singleton births which incorporated all midpelvic live or stillbirths via forceps or vacuum and C-section deliveries between 37 and 41 days of gestational age. Of these, 76,755 women needed intervention due to poor uterine contractions and 110,479 due to foetal distress.

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New approach to slow lower cancer growth found

By: PTI Wasington Printed:May 30, 2017 5:35 pm

Lifestyle and health, cancer, disease cancer, cancer causes, cancer treatment, lung cancer, cancer patients, prevention of cancer, cancer and death, research on cancer, cancer study, indian express, indian express news

A singular treatment solution is located to deal with deadly disease ‘cancer.’ (Source: ThinkStock Images)

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Scientists have identified a different way to slow lower the development of cancer cells, funding that can lead to novel treatments from the deadly disease.

Researchers in the College of Rochester in america identified a protein known as Tudor-SN that’s essential in the”preparatory” phase from the cell cycle – the time once the cell will get prepared to divide.

ALSO READ How can your stomach fat increase the chance of cancer? Continue reading to know

When scientists eliminated this protein from cells, while using gene editing technology CRISPR-Cas9, cells required longer to prepare for division. Losing Tudor-SN slowed the cell cycle.

“We realize that Tudor-SN is much more rich in cancer cells than healthy cells, and our study shows that targeting this protein could hinder fast-growing cancer cells,” stated Reyad A Elbarbary, lead study author and research assistant professor at Rochester.

Elbarbary stated there are existing compounds that block Tudor-SN that may be good candidates for any possible therapy. Based on senior study author Lynne E Maquat, Tudor-SN influences the cell cycle by controlling micro RNAs, molecules that tweak the expression of a large number of human genes.

When Tudor-SN is taken away from human cells, the amount of a large number of micro RNAs increase. Boosting the existence of micro RNAs puts the brakes on genes that encourage cell growth.

Using these genes within the “off” position, the cell moves more gradually in the preparatory phase towards the cell division phase. “Because cancer cells possess a faulty cell cycle, going after factors active in the cell cycle is really a promising avenue for cancer treatment,” stated Maquat.

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Air Beds Associated with Greater Than 100 Infant Deaths

News Picture: Air Mattresses Linked to More Than 100 Infant Deaths

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FRIDAY, June 2, 2017 (HealthDay News) — An air bed could be a harmful spot for babies, researchers warn.

Air beds have become growing well-liked by low-earnings, transient people because of their affordable cost and portability. However these beds carry significant risks for infants, including the potential of dying, based on the study authors.

“Even if fully inflated, air beds can mold towards the infant’s face and obstruct the airway by developing an occlusive seal,” authored researchers Jennifer Doering, in the College of Wisconsin-Milwaukee, and Trina Salm Ward, in the College of Georgia.

“The danger increases when air beds leak during use. Underinflation would be a element in a few of the infant deaths reviewed,” they added.

There have been 108 infant deaths involving air beds reported in 24 states between 2004 and 2015, based on the U.S. National Child Dying Review Situation Reporting System. However the researchers stated such deaths are most likely underreported. There is no specific box to check on to mark a dying as associated with an air bed, the research authors described.

They checked policy statements from 12 organizations — including federal agencies and health, consumer and parent groups — and located that just one pointed out the hazard posed to infants by air beds.

Doering and Ward known as for improved data collection on air bed-related infant deaths as well as for more public health organizations to warn concerning the threat.

The research was printed lately within the American Journal of Public Health.

— Robert Preidt

MedicalNews
Copyright © 2017 HealthDay. All legal rights reserved.

SOURCE: College of Wisconsin-Milwaukee, news release, May 25, 2017

Wish to fight stress? Put on this wristband better than like heart

By: PTI Washington Printed:May 30, 2017 7:29 pm

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A wristband might help in lessening stress. (Source: File Photo)

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A wearable device that gives heartbeat-like vibrations onto within the wrist can considerably reduce stress, new research finds.

Humans naturally react to rhythm. For instance, the tempo of the song can naturally alter our breathing and heart rates, researchers stated. Slower tempos lead to lower arousal and positive or calm emotional states, basically we affiliate fast rhythms with arousing emotional states for example pleasure, excitement, surprise, fear or anger.

ALSO READ  Wristband that will help tackle depression

Researchers from College based in london within the United kingdom assessed the calming results of the unit known as doppel – a wristband made to positively reduce stress using the intuitive responses that everyone has to rhythm, and particularly to heartbeats.

Beyond music, several studies report similar effects in responses to biological rhythms, and also the heartbeat is possibly probably the most ubiquitous biological rhythm anyway. “High arousal is correlated with elevated heartbeat, whereas calmness is physiologically correlated with lower heartbeat,Inches stated Manos Tsakiris from College based in london.

“We also without effort affiliate greater minimizing heartbeat with anxiety or high arousal, and quietness. The style of doppel, the unit that people utilized in our study, was inspired by this,Inches stated Tsakiris.

To check the effectiveness of doppel, they uncovered volunteers to some socially demanding situation and measured their physiological arousal as well as their reported anxiety levels. Two categories of participants were requested to organize an open speech, a broadly used mental task that consistently increases stress.

All participants used the unit on their own wrist along with a cover story was utilized to point out to participants the device was calculating bloodstream pressure throughout the anticipation from the task. For among the two groups, the unit was switched on and delivered a heartbeat-like vibration in a slower frequency compared to participants’ resting heartbeat, when they were preparing their speech.

They measured both physiological arousal and subjective reports of tension.

Using doppel were built with a tangible and measurable calming effect across both physiological and mental levels. Just the participants who felt the heartbeat-like vibration displayed lower increases in skin conductance responses minimizing anxiety levels. “Wearable products are becoming ubiquitous in everyday existence, but overall their primary aim would be to evaluate our activity,” stated Tsakiris.

“The results we’ve got claim that, instead of calculating ourselves, we are able to rather harvest our natural responses to heartbeat like rhythms with techniques that can help individuals their everyday existence,” he stated.

The study was printed within the journal Scientific Reports.

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