Rapid, Easy Zika Test Developed

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News Picture: Rapid, Easy Zika Test DevelopedBy Dennis Thompson
HealthDay Reporter

WEDNESDAY, Sept. 27, 2017 (HealthDay News) — A brand new fast, simple and easy , cheap “dipstick” test for that Zika and dengue infections could transform public health reaction to harmful tropical germs, new research reports.

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The exam precisely diagnoses Zika and dengue and may tell the 2 bug-borne infections apart, a place by which commercially accessible tests now stumble, stated senior investigator Lee Gehrke, a professor using the Durch Institute for Medical Engineering and Science.

“Considering the issues with Zika virus causing microcephaly [an inherited abnormality producing a smaller sized-than-normal mind] along with other defects in infants born to infected moms, it is important an expectant lady knows if her fever is because Zika virus or dengue virus,” stated Gehrke, who’s additionally a professor at Harvard School Of Medicine.

The brand new test resembles getting pregnant test strip, Gehrke noted. The strip contains antibodies that respond to the existence of Zika or dengue virus, and gold nanoparticles that react to the antibody reaction.

To make use of the exam, your personal doctor would dip the strip right into a tube of either bloodstream serum or whole bloodstream.

“If it’s an optimistic test, only then do we visit a us dot or perhaps a line around the test that is a result of seeing the gold nanoparticles that signal the antibodies recognizing the viral protein,” Gehrke stated.

The exam will easily notice Zika from dengue, as well as can distinguish among four different strains of dengue, Gehrke added.

Zika and dengue both fit in with exactly the same viral family, that are known as flaviviruses.

“They’re two carefully related infections spread through the same bug,” stated co-investigator Kimberly Hamad-Schifferli, an affiliate professor of engineering using the College of Massachusetts in Boston.

The study team, that also incorporated people from Mount Sinai Med school in New You are able to City, developed the brand new test because current testing products sometimes mix-react between Zika and dengue, supplying an incorrect positive for Zika once the patient really has got the other virus, Gehrke stated.

Researchers checked the precision from the test by testing bloodstream serum samples obtained from individuals regions where Zika has hit hardest, including South america, Colombia, Guatemala, India, Mexico and Panama. Serious birth defects brought on by Zika made an appearance the very first time within the western hemisphere in 2015 in northern South america then your epidemic taken outward.

“We validated the exam within the places that herpes is located, using human serum from infected patients,” Gehrke stated. “This isn’t only a test we performed using materials inside a laboratory. We really traveled towards the endemic areas.”

The exam demonstrated 80 % to 90 % accurate in discovering Zika and staying away from false positives, Hamad-Schifferli stated.

It will require in regards to a year to obtain the test available in Zika-affected regions, because the technology is dependant on existing items like pregnancy tests, Hamad-Schifferli stated.

The exam is also expected to be really affordable. Presently, material pricing is about $5 per strip, but Gehrke stated costs should decline as production will get moving.

“Our target is under $1 per strip, which we believe is affordable when the antibody production is scaled up,” Gehrke stated. “The gold nanoparticles happen to be quite affordable.”

Infectious disease expert Dr. Amesh Adalja stated the brand new test “will fulfill an excellent need and become of quality value.

“The supply of rapid, sensitive and particular tests is vital for that identification, treatment, and charge of infectious disease,” stated Adalja, a senior affiliate using the Johns Hopkins Center for Health Peace of mind in Baltimore.

He added, “That the rapid antigen test that fits this criteria is achievable for dengue and Zika — two clinically indistinguishable illnesses with various prognoses — is really a major advance.Inch

The brand new report seems Sept. 27 within the journal Science Translational Medicine.

MedicalNews
Copyright © 2017 HealthDay. All legal rights reserved.

SOURCES: Lee Gehrke, Ph.D., professor, Massachusetts Institute of Technology, Institute for Medical Engineering and Science, and professor, Harvard School Of Medicine, Cambridge, Mass. Kimberly Hamad-Schifferli, Ph.D., affiliate professor, engineering, College of Massachusetts, Boston Amesh Adalja, M.D., senior affiliate, Johns Hopkins Center for Health Security, Baltimore Sept. 27, 2017, Science Translational Medicine

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